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NOW AVAILABLE: LeviCell 96, fully automated sample prep on standard SBS robotics
LevitasBio
  • products | LEVICELL 96

LeviCell 96 System

Fully automated, label-free sample prep on the robotics you already run

Enrich, wash, pellet, image, analyze, collect, pool and concentrate cells, nuclei, organoids and particles, with up to 96 samples per run in SBS format. Run it as a complete system with an INTEGRA liquid handler, or add the LeviCell 96 Pro array to the robotics you already own. The result is high-fidelity, reproducible data at a fraction of the cost.

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>95%

viability after enrichment

96

samples per run

$10

per sample, instead of $100+

3

hands-on steps for 96 samples

  • Two ways to run it

LeviCell 96 System or LeviCell 96 Pro

LeviCell 96 System

The complete platform: the SALT™ 96-well levitation array together with an INTEGRA liquid handler, installed, validated and supported as one system. The fastest route to walkaway sample prep for labs that do not yet run SBS robotics.

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LeviCell 96 Pro

The SALT™ 96-well levitation array and reagents on their own, for labs that already run SBS-compatible liquid handling. Drop the array into a standard deck position and run the LeviCell protocols on the robot you already own.

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  • The bottleneck

Sample prep is the last manual step between your robot and your data

Sequencing, cytometry and imaging have scaled. Sample prep has not. Centrifuges, filters and bead cleanups still need hands, add stress to cells and change from operator to operator. That variability ends up in your datasets as noise and batch effects, and it becomes the ceiling on how many samples you can run.

The LeviCell 96 replaces those steps with Levitation Technology™ on a 96-well SBS plate, so the whole prep can run on a liquid handler with your team off the pipette.

  • One automated workflow

Eight steps, one deck, no centrifuge

Enrich

Separate viable cells or nuclei from dead cells and debris by levitation.

Wash

Run sequential buffer exchanges in the well, with no centrifuge spins.

Pellet

Levitation gathers viable cells into a tight pellet above dead cells and debris, with no centrifuge.

Image

LeviCell Insight, our standalone brightfield imager, images every well of the array at once in about five minutes.

Analyze

Check cell health, aggregation and purity in every well from the LeviCell Insight images before you commit downstream.

Collect

Aspirate the fraction of interest and leave the waste behind.

Pool

Combine wells or replicates on the deck to fit your study design.

Concentrate

Elute in small volumes, ready for loading into downstream assays.

  • Built for automation

Designed for the robot deck

The proprietary Selective Arrayed Levitation Technology (SALT™) array runs 96 levitation reactions at once in a SLAS/SBS 96-well ANSI footprint. It sits in a standard deck position next to your tips, input plate and output plate.

  • Scripted protocols: viable cell enrichment, cell washing and nuclei workflows run as programs on the liquid handler
  • Walkaway runs: load the plate, start the program and come back to samples ready for counting and downstream use
  • No extra devices: no centrifuge, filters, magnetic beads, labels or microfluidics to integrate
  • Well-to-well consistency: identical processing in every well removes manual variability
  • Data at scale

Model-ready data, sample after sample

Large models of cell biology, such as virtual cell models, perturbation atlases and foundation-scale single-cell and organoid datasets, are only as good as the samples behind them. The LeviCell 96 System produces inputs that are clean, consistent and documented across thousands of samples.

  • High fidelity: more than 95% viability with debris removed, so less noise and ambient signal downstream
  • Unbiased: no stains, markers, high pressure or shear, and activation and expression states are maintained
  • Reproducible: identical, scripted processing in every well delivers more than 95% viability run after run
  • Affordable at scale: about $10 per sample instead of more than $100

LeviCell 96 System vs. standard methods

Faster, higher-yield and fully automated, without the limits of centrifugation and filtration.

FeatureLeviCell 96 SystemCentrifugation and filtration
Time to enriched cells45 minutesSeveral hours
Levitation time40 minutesNot applicable
Hands-on time5 minutesLabor-intensive
Hands-on steps3Many
Cell viability>95%Lower, due to mechanical stress
Debris removal60%Varies
Viable cell yieldUp to 5X more than centrifugation and filtrationBaseline, reduced by cell loss at every spin
AutomationFully automatedManual steps required
Robotics formatStandard SBS / ANSI 96-wellCentrifuge integration needed
Label-freeYesNo

Flexible, simple and fast

The LeviCell 96 System isolates targeted cells without labels or markers and processes up to 500,000 cells per well, with inputs as low as 15,000 cells. It outperforms standard wash and concentration workflows and delivers high-purity outputs even from very low input cell numbers.

Sample flexibility

  • Cells, nuclei, organoids and particles
  • Non-adherent and adherent cells, from bacteria to organoids
  • Tolerant of debris and contaminants

Unbiased cellular profile and response

  • No stains or markers
  • No high pressures or microfluidics
  • Maintains activation and expression states

Multiplex with LeviSelect assays

  • Targeted depletion alongside enrichment
  • Image every well with the standalone LeviCell Insight
  • Standard SBS format

What changes on your bench

5X

more viable cells than centrifugation and filtration

  • 5X more viable cells than centrifugation and filtration
  • 10X less myelin and debris
  • >99% targeted cell removal

96

samples in parallel, 45 minutes to enriched cells

  • Cell washing
  • Sample enrichment
  • Debris removal

$10

per sample, instead of $100+

  • $10 vs >$100
  • 45 min to enriched cells
  • Walkaway automation

The LeviCell 96 System turns slow, inconsistent manual workflows into a streamlined, automated process. It delivers high-purity results that speed up discovery and scale to the dataset sizes that large models need.

Key applications

This fully automated system is flexible and reproducible across many workflows, because Levitation Technology adapts to each application.

Flow cytometry workflow illustration

Flow cytometry

  • Pre-sort viability enrichment
  • Cell washing

CITE-seq and antibody workflow illustration

CITE-seq and antibody workflows

  • Pre-encapsulation viability enrichment
  • Centrifuge-free washes for CITE-seq and CUT&Tag

Single-cell sequencing data illustration

scRNA-seq and snRNA-seq

  • Pre-encapsulation viability enrichment
  • Nuclei clean-up and washing

Applications beyond live cell enrichment

Primary cell dose response

Dissociated tumors, multi-cell-type samples, plant and bacterial cells, and nuclei.

Organoid testing

Whole or dissociated organoids, fractional cell response, and death and activation readouts, all in 96-well format for screening.

Cell-cell interaction

Killing assays, cell-cell binding and multi-cell-type experiments.

Automated nuclei clean-up

Debris and aggregates cleaned up from nuclei preps; nuclei washed and collected ready to load.

LeviCell 96 System performance

The LeviCell 96 System takes 96 samples from loading to enriched cells in 45 minutes, with 5 minutes hands-on.

>95%

viability after enrichment

5X

more viable cells than centrifugation and filtration

45 min

to enrich 96 samples: 5 min hands-on, 40 min of levitation

Application example: live cell enrichment

>50%

yield

>95%

viability

60%

debris removal

5 min

hands-on time

Three hands-on steps per 96 wells: 5 minutes hands-on, 40 minutes of levitation, 45 minutes to enriched cells.

Application example: PBMC cell washing for cytometry

>70%

yield

>95%

viability

Yes

debris removal, with subpopulations maintained

5 min

hands-on time

Three hands-on steps per 96 wells: 5 minutes hands-on, 40 minutes of levitation, 45 minutes to washed cells.

Ordering info

Ready to automate your sample prep and scale your data?

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  • LeviCell 96 System (SALT array with INTEGRA liquid handler), 1-year warranty PN 1000060
  • LeviCell 96 Pro (SALT array for your own SBS robotics): ask us for a quote
  • LeviCell Insight imaging system: ask us for a quote
  • LeviCell 96 Complete Enrichment Kit (10 runs) PN 1002201
  • LeviCell 96 Complete Cell Washing Kit (10 runs) PN 1002202
  • LeviCell 96 Extended Service Plan, 1 Year Coverage PN 1110025
  • LeviCell 96 Extended Service Plan, 2 Year Coverage PN 1110026
  • LeviCell 96 Extended Service Plan, 3 Year Coverage PN 1110027

Talk to a specialist about the LeviCell 96

Tell us about your deck, your sample types and your throughput targets. We'll help you plan integration, protocols and purchase options.