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June 10, 2023
Debora Gisch, PhD, and colleagues pioneered a comprehensive epigenomic atlas of the kidney, shedding light on its cellular response to injury and repair. Utilizing the LeviCell® systems, they purified nuclei from precious kidney biopsy samples and healthy tissue, ensuring high-quality inputs for subsequent single nuclei RNA-seq and ATAC-seq analyses, elucidating the chromatin landscape in kidney reference and adaptive injury states.
May 17, 2023
Through a high-throughput screen, Holly Pariury, DO, and colleagues discovered dinaciclib’s efficacy against hypodiploid Acute Lymphoblastic Leukemia (ALL) cells. The performance of viable-cell enrichment using Levitation Technology™ accelerated the lentiviral transduction-based generation of stable isogenic cell lines with altered MCL-1 levels, revealing the CDK9/MCL-1 pathway’s central role in hypodiploid ALL and a promising new treatment approach for this aggressive cancer.
April 10, 2023
Anna Bielecka-Wajdman, PhD, and colleagues investigated proteomic changes in glioblastoma multiforme (GBM) cell lines after Temozolomide (TMZ) treatment. Further, the team used the LeviCell® 1.0 system to isolate live cells that survived the treatment efficiently, enabling the characterization of this TMZ-resistant subpopulation’s morphology and growth by microscopy. The findings provide valuable insights into GBM’s treatment resistance and highlight potential therapeutic avenues.
March 20, 2023
Utilizing the LeviCell® 1.0 system, Jan Remsik, PhD, PharmD, and colleagues successfully refined the proteogenomic analysis of delicate cerebrospinal fluid samples from leptomeningeal metastasis (LM) models via CITE-seq. The breakthrough discovery that dendritic cells, guided by IFN-γ, are central to the innate immune response against leptomeningeal metastasis presents a promising direction for new therapies, highlighting the power of Levitation Technology™ in advancing cancer research.
April 30, 2020
Nazan Puluca, PhD, and colleagues harnessed magnetic levitation to efficiently segregate cardiomyocytes (CM) based on intrinsic density variations from lipid content differences. Applied to cell lines derived from samples obtained from human subjects with neutral lipid storage disease, real-time monitoring allowed direct measurement of distinct subpopulations. Microscopy and patch-clamp electrophysiology experiments on sorted cells revealed new insights into lipid accumulation’s impact on CMs structure and function.
August 11, 2015
Murat Baday, PhD, and colleagues developed a groundbreaking diagnostic tool for blood analysis that combines the power and ubiquity of smartphones with magnetic levitation-based label-free separation of red and white blood cells for quantification through cell phone imaging. The underlying technology has been developed into the LeviCell® systems for live cell enrichment and sample quality improvement through debris removal with real-time monitoring.