Publications

This study by Jung et al. examines matrix metalloproteinases (MMPs) as biomarkers and therapeutic targets in facioscapulohumeral muscular dystrophy (FSHD). The researchers found that MMP expression strongly correlates with disease severity in FSHD patients and is elevated even in

This study by McGregor et al. describes how researchers created a detailed spatial atlas of Crohn’s disease fistulae to understand their formation and persistence. Using spatial transcriptomics and single-cell sequencing on 68 fistula samples, they identified specialized “fistula

This study by Ke et al. provides a comprehensive single-cell RNA sequencing (scRNA-seq) atlas of soil-grown wheat root apical meristems, addressing the challenge of accurate cell type annotation in less-studied crop species. The researchers developed an orthology-based annotation

Florian Constanty and colleagues investigate the involvement of border-zone cardiomyocytes and macrophages in the remodeling of the extracellular matrix (ECM) to facilitate cardiomyocyte invasion during cardiac regeneration in zebrafish. The study reveals that these border-zone cardiomyocytes and ma

Drought stress imposes severe challenges on agriculture by impacting crop performance. Understanding drought responses in plants at a cellular level is a crucial first step towards engineering improved drought resilience. However, the molecular responses to drought are complex as they depend on mult

Cardiera-da-Silva et al. investigate the role of antigen presentation in the process of heart regeneration in zebrafish, as this species possesses a remarkable ability to regenerate cardiac tissue after injury. The research found that antigen presentation, a process typically associated with the imm

Sarah Lindner, PhD, and colleagues investigate the relationship between microbial transformation of bile acids, intestinal immune homeostasis, and inflammatory pathologies. By using a model of graft-versus-host disease (GVHD), the authors were able to determine that T cell-driven inflammation decrea

Jennifer Gansau and colleagues investigate what factors contribute to the degeneration of Intervertebral discs (IVD), a condition that can lead to herniation and back pain due to the poor IVD healing capacities. The authors are able to identify distinct roles of TNFα-receptors (TNFRs) in IVD cell re

Debora Gisch, PhD, and colleagues pioneered a comprehensive epigenomic atlas of the kidney, shedding light on its cellular response to injury and repair. Utilizing the LeviCell® systems for a select number of samples, they purified nuclei from precious kidney biopsy samples and healthy tissue, ensur

Through a high-throughput screen using engineered NALM-16 cells, Holly Pariury, DO, and colleagues discovered that dinaciclib enhances the anti-leukemic effect of venetoclax against hypodiploid Acute Lymphoblastic Leukemia (ALL), an aggressive blood cancer disease with poor prognosis. After lentivir

Anna Bielecka-Wajdman, PhD, and colleagues investigated proteomic changes in glioblastoma multiforme (GBM) cell lines after Temozolomide (TMZ) treatment. Further, the team used the LeviCell® 1.0 system to efficiently isolate live cells that survived the treatment, enabling the characterization of th

Utilizing the LeviCell® 1.0 system, Jan Remsik, PhD, PharmD, and colleagues successfully refined the proteogenomic analysis of delicate cerebrospinal fluid samples from leptomeningeal metastasis (LM) models via CITE-seq. The breakthrough discovery that dendritic cells, guided by IFN-γ, are central t

Nazan Puluca, PhD, and colleagues harnessed magnetic levitation to segregate cardiomyocytes (CM) based on intrinsic density variations from lipid content differences. Applied to cell lines derived from samples obtained from human subjects with neutral lipid storage disease, real-time monitoring of t

Murat Baday, PhD, and colleagues developed a groundbreaking diagnostic tool for blood analysis that combines the power and ubiquity of smartphones with magnetic levitation-based label-free separation of red and white blood cells for quantification through cell phone imaging. The underlying technolog

Savas Tasoglu, PhD, and colleagues applied magnetic levitation to rapidly segregate blood cells and circulating tumor cells based on their unique magnetic and density signatures. Based on the fact that distinct magnetic signatures can be correlated to different cellular mechanisms, this approach can

In this groundbreaking study, Naside Gozde Durmus, PhD, and colleagues developed the ‘MagDense’ system, the precursor of the LeviCell® systems, which could rapidly and precisely profile diverse eukaryotic and prokaryotic cell types using magnetic levitation. This approach identifies distinctive cell