Spotlight on Laboratory Experiments and Protocols

Last week, we discussed labs’ increasing emphasis on discovering the individual cellular origin of disease. Although both single-cell RNA sequencing (scRNA-Seq) and single-nucleus RNA sequencing (snRNA-Seq) are used to characterize the transcriptional profile of individual cells, scRNA-Seq analyses are confounded in, for example, the case of large cells

Single Cell / Single Nuclei Genomic Profiling is Fundamental to the Future of Biology

The genome, epigenome, transcriptome and proteome are usually distinct for each of the 40 trillion cells in the human body. This cellular heterogeneity means that to fully understand physiology, and the etiology of thousands of genetic-origin diseases afflicting mankind, biologists must have an understanding of the individual cellular origin of disease. If an experiment is […]